2-Amino-4-methylthiazole → HCID 86674028, compound

HRID 2284322Notes

Reaction equation

HRID 2284322 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([C:11]1[CH:19]=[CH:18][C:14]([C:15](O)=[O:16])=[CH:13][CH:12]=1)[CH:6]=[CH:5]2.[NH2:20][C:21]1[S:22][CH:23]=[C:24]([CH3:26])[N:25]=1.[OH:27][CH:28]1[CH2:33][CH2:32][N:31]([C:34]2[CH:42]=[CH:41][C:37]([C:38](O)=[O:39])=[CH:36][CH:35]=2)[CH2:30][CH2:29]1>>[OH:27][CH:28]1[CH2:29][CH2:30][N:31]([C:34]2[CH:42]=[CH:41][C:37]([C:38]([NH:1][C:2]3[CH:3]=[C:4]4[C:8](=[CH:9][CH:10]=3)[N:7]([C:11]3[CH:19]=[CH:18][C:14]([C:15](=[O:16])[NH:20][C:21]5[S:22][CH:23]=[C:24]([CH3:26])[N:25]=5)=[CH:13][CH:12]=3)[CH:6]=[CH:5]4)=[O:39])=[CH:36][CH:35]=2)[CH2:32][CH2:33]1

Participants

4

Reactant 3

HCID 741432-Amino-4-methylthiazoleHCID 186175914-(4-Hydroxy-1-piperidinyl)benzoic acidHCID 67112874HCID 67112874, compound

Product 1

HCID 86674028HCID 86674028, compound

Procedure

Compound 954 was prepared according to the procedure described in Scheme IV from 4-(5-amino-1H-indol-1-yl)benzoic acid, 2-amino-4-methylthiazole, and 4-(4-hydroxypiperidin-1-yl)benzoic acid. [M+H]+ calcd for C31H29N5O3S: 552.10; found: 552.05.

Sources & evidence

ORD record
ord-e5554b7fbabd47738e6bf3e8f9d38d0a
Source dataset
uspto-grants-2015_09
Patent number
US09144557B2

Reaction notes

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