tert-Butyl bromoacetate → HCID 67687710, compound

HRID 2284335Notes

Reaction equation

HRID 2284335 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([C:11]1[CH:16]=[CH:15][C:14]([NH2:17])=[CH:13][CH:12]=1)[N:6]=[CH:5]2.Br[CH2:19][C:20]([O:22][C:23]([CH3:26])([CH3:25])[CH3:24])=[O:21].[O:27]1[CH2:32][CH2:31][N:30]([C:33]2[CH:41]=[CH:40][C:36]([C:37](O)=[O:38])=[CH:35][CH:34]=2)[CH2:29][CH2:28]1>>[O:27]1[CH2:28][CH2:29][N:30]([C:33]2[CH:34]=[CH:35][C:36]([C:37]([NH:1][C:2]3[CH:3]=[C:4]4[C:8](=[CH:9][CH:10]=3)[N:7]([C:11]3[CH:16]=[CH:15][C:14]([NH:17][CH2:19][C:20]([O:22][C:23]([CH3:26])([CH3:25])[CH3:24])=[O:21])=[CH:13][CH:12]=3)[N:6]=[CH:5]4)=[O:38])=[CH:40][CH:41]=2)[CH2:31][CH2:32]1

Participants

4

Reactant 3

HCID 79177tert-Butyl bromoacetateHCID 3452784-(Morpholin-4-yl)benzoic acidHCID 834142075-Amino-1-(4-aminophenyl)indazole

Product 1

HCID 67687710HCID 67687710, compound

Procedure

Compound 987 was prepared according to the procedure described in Scheme IV from 5-amino-1-(4-aminophenyl)indazole, t-butyl bromoacetate, and 4-morpholinobenzoic acid. 1H NMR (500 MHz, CDCl3) δ 8.15 (s, 1H), 8.09 (s, 1H), 7.98 (s, 1H), 7.84 (d, J=7.5 Hz, 2H), 7.55 (d, J=9 Hz, 1H), 7.48 (d, J=10 Hz, 1H), 7.46 (d, J=7 Hz, 2H), 7.26 (s, 1H), 6.90 (d, J=7.5 Hz, 2H), 6.71 (d, J=7 Hz. 2H), 4.45 (s, 1H), 3.87-3.83 (m, 6H), 3.27-3.25 (m, 4H), 1.51 (m, 9H).

Sources & evidence

ORD record
ord-4c984545b6cb49f19d40467967135a6d
Source dataset
uspto-grants-2015_09
Patent number
US09144557B2

Reaction notes

Loading…