Sulfuric Acid → 1H-Indole-2,3-dione, 6-bromo-

Participants

Reaction Conditions

Reaction Steps

To concentrated sulfuric acid (275 mL) at 50° C. was added N-(3-bromo-phenyl)-2-hydroxyimino-acetamide (55 g, 0.2272 mol). The temperature was raised to 90° C. and maintained for 3 hours. The reaction mixture was added to ice cold water to provide a yellow precipitate. The precipitate was filtered and dried to provide the title compound as a yellow solid (50 g, 98%). This material was taken for next step without any further purification.

Provenance & Evidence