反应详情

温度

90 °C

To concentrated sulfuric acid (40 mL) at 50° C. was added N-(3-bromo-4-fluoro-phenyl)-2-hydroxyimino-acetamide (4 g, 0.0152 mol). The temperature was raised to 90° C. and maintained for 3 hours. The reaction mixture was added to ice cold water to provide a precipitate. The precipitate was filtered and dried to provide the title compound (3.0 g, 80%).

1. temperaturemaintained for 3 hours
2. additionThe reaction mixture was added to ice cold water
3. customto provide a precipitate
4. filtrationThe precipitate was filtered
5. customdried