Sulfuric Acid → 6-Bromo-5-fluoroindoline-2,3-dione

Participants

Reaction Conditions

Reaction Steps

To concentrated sulfuric acid (40 mL) at 50° C. was added N-(3-bromo-4-fluoro-phenyl)-2-hydroxyimino-acetamide (4 g, 0.0152 mol). The temperature was raised to 90° C. and maintained for 3 hours. The reaction mixture was added to ice cold water to provide a precipitate. The precipitate was filtered and dried to provide the title compound (3.0 g, 80%).

Provenance & Evidence