反应详情

温度

200 °C

To a 100 mL round bottom flask, 2-amino-4-bromo-5-fluoro-benzoic acid (0.7 g, 2.99 mmol) and urea (1.07 g, 17.94 mmol) were added. The reaction mixture was stirred at 200° C. for 2 hours. The reaction mixture was allowed to cool to 100° C. and water was added. The aqueous reaction mixture was refluxed for 5-10 minutes and cooled to room temperature to provide the precipitate. The solid was filtered and dried to afford the title compound (400 mg, 51%). This material was taken to the next step without further purification.

1. temperatureto cool to 100° C.
2. temperatureThe aqueous reaction mixture was refluxed for 5-10 minutes
3. temperaturecooled to room temperature
4. customto provide the precipitate
5. filtrationThe solid was filtered
6. customdried