1,1,1-Trifluoro-2-iodoethane → 1-(2,2,2-trifluoroethyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine

HRID 2284452Notes

Reaction equation

HRID 2284452 reaction equation
[NH:1]1[C:5]2=[CH:6][N:7]=[CH:8][CH:9]=[C:4]2[CH:3]=[N:2]1.[F:10][C:11]([F:15])([F:14])[CH2:12]I>[Pt](=O)=O>[F:10][C:11]([F:15])([F:14])[CH2:12][N:1]1[C:5]2[CH2:6][NH:7][CH2:8][CH2:9][C:4]=2[CH:3]=[N:2]1

Participants

4

Reactant 2

HCID 677091,1,1-Trifluoro-2-iodoethaneHCID 64514411H-Pyrazolo[3,4-c]pyridine

Product 1

HCID 1176783841-(2,2,2-trifluoroethyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine

Reagents, catalysts & solvents 1

HCID 345198Adams' catalystCatalyst

Procedure

1H-Pyrazolo[3,4-c]pyridine was alkylated with 1,1,1-trifluoro-2-iodoethane, then reduced via hydrogenation over platinum(IV) oxide to afford 1-(2,2,2-trifluoroethyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine.

Sources & evidence

ORD record
ord-c8b2a84bbaa2432fa4aa11ce9ba5810a
Source dataset
uspto-grants-2015_09
Patent number
US09145427B2

Reaction notes

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