2-cyclopropoxyethanol → HCID 66726625, compound

HRID 2284512Notes

Reaction equation

HRID 2284512 reaction equation
Cl[C:2]1[N:10]=[C:9](Cl)[C:8]([Cl:12])=[CH:7][C:3]=1[C:4]([NH2:6])=O.[CH:13]1([O:16][CH2:17][CH2:18][OH:19])[CH2:15][CH2:14]1.[B:20]1([OH:30])[C:24]2[CH:25]=[CH:26][C:27]([OH:29])=[CH:28][C:23]=2[CH2:22][O:21]1>>[Cl:12][C:8]1[C:9]([O:29][C:27]2[CH:26]=[CH:25][C:24]3[B:20]([OH:30])[O:21][CH2:22][C:23]=3[CH:28]=2)=[N:10][C:2]([O:19][CH2:18][CH2:17][O:16][CH:13]2[CH2:15][CH2:14]2)=[C:3]([CH:7]=1)[C:4]#[N:6]

Participants

4

Reactant 3

HCID 120233832-cyclopropoxyethanolHCID 537509302,5,6-Trichloropyridine-3-carboxamideHCID 579686991,3-Dihydro-1-hydroxy-2,1-benzoxaborol-5-ol

Product 1

HCID 66726625HCID 66726625, compound

Procedure

This compound was prepared from 2,5,6-trichloronicotinamide, 2-cyclopropoxyethanol, and benzo[c][1,2]oxaborole-1,5(3H)-diol in a similar manner to that of D230. 1H-NMR (400 MHz, DMSO-d6) δ (ppm) 0.35-0.4 (m, 4H), 3.2-3.32 (m, 1H), 3.55-3.62 (m, 3H), 4.1-4.12 (m, 2H), 5.0 (s, 2H), 7.24 (dd, J=6.0, 1.4 Hz, 1H), 7.33 (s, 1H), 7.8 (d, J=6.7 Hz, 1H), 8.6 (s, 1H), 9.26 (s, 1H).

Sources & evidence

ORD record
ord-72593f2bd6724e6a9b71d40f3c241e06
Source dataset
uspto-grants-2015_09
Patent number
US09145429B2

Reaction notes

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