HRID2284696

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID68275132

未命名化合物

HCID90052036

未命名化合物

PRODUCTS

生成物

结构：CCCNc1nc(Nc2ccc(C#N)cc2)ncc1C(=O)Nc1cccc(NC(=O)CNC(=O)OC(C)(C)C)c1

HCID90051987

未命名化合物

PROCEDURE

实验过程

By using tert-butyl (2-((3-aminophenyl)amino)-2-oxoethyl)carbamate (B1) and 2-((4-cyanophenyl)amino)-4-(propylamino)pyrimidine-5-carboxylic acid (C5), tert-butyl (2-((3-(2-((4-cyanophenyl)amino)-4-(propylamino)pyrimidine-5-carboxamido)phenyl)amino)-2-oxoethyl)carbamate (D8) was obtained in the same manner as that of Example 12, (1).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-a8748bd8bc7e41d5b0662145a01d8e1b
来源数据集: uspto-grants-2015_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09145415B2
来源说明: uspto-grants-2015_09

反应 SMILES

[NH2:1][C:2]1[CH:3]=[C:4]([NH:8][C:9](=[O:19])[CH2:10][NH:11][C:12](=[O:18])[O:13][C:14]([CH3:17])([CH3:16])[CH3:15])[CH:5]=[CH:6][CH:7]=1.[C:20]([C:22]1[CH:27]=[CH:26][C:25]([NH:28][C:29]2[N:34]=[C:33]([NH:35][CH2:36][CH2:37][CH3:38])[C:32]([C:39](O)=[O:40])=[CH:31][N:30]=2)=[CH:24][CH:23]=1)#[N:21]>>[C:20]([C:22]1[CH:23]=[CH:24][C:25]([NH:28][C:29]2[N:34]=[C:33]([NH:35][CH2:36][CH2:37][CH3:38])[C:32]([C:39]([NH:1][C:2]3[CH:3]=[C:4]([NH:8][C:9](=[O:19])[CH2:10][NH:11][C:12](=[O:18])[O:13][C:14]([CH3:15])([CH3:16])[CH3:17])[CH:5]=[CH:6][CH:7]=3)=[O:40])=[CH:31][N:30]=2)=[CH:26][CH:27]=1)#[N:21]