HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Hydrochloric Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | tert-butyl ((1S,3R)-3-ethynylcyclohexyl)carbamate | HCID 90051794 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | Hydrochloric Acid | HCID 313 | — |
| Product | HCID 90051816 | HCID 90051816 | — |
Reaction Steps
To tert-butyl ((1S,3R)-3-ethynylcyclohexyl)carbamate (P0, 1.4 g), a 4.0 mol/L solution of hydrochloric acid in 1,4-dioxane (30 mL) was added at room temperature, and the mixture was stirred at room temperature for 1 hour. The solvent was evaporated under reduced pressure to obtain (1S,3R)-3-ethynylcyclohexaneamine (U1) hydrochloride as white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09145415B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-45f993f55bae43cbb923c77e7240450c |
| Source note | uspto-grants-2015_09 |