Hydrochloric Acid → Hydrochloric Acid

HRID 2284819Notes

Reaction equation

HRID 2284819 reaction equation
[C:1]([C@@H:3]1[CH2:8][CH2:7][CH2:6][C@H:5]([NH:9]C(=O)OC(C)(C)C)[CH2:4]1)#[CH:2].[ClH:17]>O1CCOCC1>[C:1]([C@@H:3]1[CH2:8][CH2:7][CH2:6][C@H:5]([NH2:9])[CH2:4]1)#[CH:2].[ClH:17]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 90051794tert-butyl ((1S,3R)-3-ethynylcyclohexyl)carbamate

Product 2

HCID 313Hydrochloric AcidHCID 90051816HCID 90051816, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To tert-butyl ((1S,3R)-3-ethynylcyclohexyl)carbamate (P0, 1.4 g), a 4.0 mol/L solution of hydrochloric acid in 1,4-dioxane (30 mL) was added at room temperature, and the mixture was stirred at room temperature for 1 hour. The solvent was evaporated under reduced pressure to obtain (1S,3R)-3-ethynylcyclohexaneamine (U1) hydrochloride as white solid.

Workup

  1. customThe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-45f993f55bae43cbb923c77e7240450c
Source dataset
uspto-grants-2015_09
Patent number
US09145415B2

Reaction notes

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