ethyl 3-(5-amino-3-tert-butyl-1H-pyrazol-1-yl)benzoate → 3-[3-tert-Butyl-5-(2,2,2-trichloro-ethoxycarbonylamino)-pyrazol-1-yl]-benzoic acid ethyl ester

HRID 2284976Notes

Reaction equation

HRID 2284976 reaction equation
[CH2:1]([O:3][C:4](=[O:21])[C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([N:11]2[C:15]([NH2:16])=[CH:14][C:13]([C:17]([CH3:20])([CH3:19])[CH3:18])=[N:12]2)[CH:6]=1)[CH3:2].[Cl:22][C:23]([Cl:47])([Cl:46])[CH2:24][O:25][C:26](=[O:45])NC1N(C2C=CC=C(CO)C=2)N=C(C(C)(C)C)C=1>>[CH2:1]([O:3][C:4](=[O:21])[C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([N:11]2[C:15]([NH:16][C:26]([O:25][CH2:24][C:23]([Cl:47])([Cl:46])[Cl:22])=[O:45])=[CH:14][C:13]([C:17]([CH3:20])([CH3:19])[CH3:18])=[N:12]2)[CH:6]=1)[CH3:2]

Participants

3

Reactant 2

HCID 21867322ethyl 3-(5-amino-3-tert-butyl-1H-pyrazol-1-yl)benzoateHCID 86687007[5-tert-Butyl-2-(3-hydroxymethyl-phenyl)-2H-pyrazol-3-yl]-carbamic acid 2,2,2-trichloro-ethyl ester

Product 1

HCID 866870083-[3-tert-Butyl-5-(2,2,2-trichloro-ethoxycarbonylamino)-pyrazol-1-yl]-benzoic acid ethyl ester

Procedure

The title compound was prepared from Intermediate 29a using an analogous procedure to that described for Intermediate 29c. LCMS (Method 3): Rt 4.67 min, m/z 462, 464 [MH+].

Sources & evidence

ORD record
ord-847169bcdaf340ebbe7e5916f9a5f7fc
Source dataset
uspto-grants-2015_09
Patent number
US09145413B2

Reaction notes

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