反应详情

Ethyl 2-(6,7-dimethoxyquinolin-4-yloxy)-5-methoxybenzoate (143 mg) and lithium hydroxide (78 mg) were suspended in a mixed solvent composed of ethanol (10 ml) and water (1 ml), and the suspension was stirred at room temperature overnight. The solvent was then removed therefrom by distillation under the reduced pressure. Water was added to the residue, and the resultant solution was neutralized with 12N hydrochloric acid. The mixture was then extracted with chloroform. The chloroform layer was washed with water and saturated brine and was dried over anhydrous sodium sulfate. The solvent was removed therefrom by distillation under the reduced pressure to give the title compound (140 mg, yield 100%).

1. customThe solvent was then removed
2. distillationby distillation under the reduced pressure
3. additionWater was added to the residue
4. extractionThe mixture was then extracted with chloroform
5. washThe chloroform layer was washed with water and saturated brine
6. dry with materialwas dried over anhydrous sodium sulfate
7. customThe solvent was removed
8. distillationby distillation under the reduced pressure