反应详情

温度

160 °C

4-Chloro-6,7-dimethoxyquinoline (1.33 g) and 2-bromo-4-methylphenol (2.5 ml) were dissolved in o-dichlorobenzene (3 ml), and the solution was stirred at 160° C. for 5 hr. The reaction solution was cooled to room temperature, and water was then added to the reaction solution. The mixture was extracted with ethyl acetate. The ethyl acetate layer was then washed with aqueous sodium hydroxide solution and saturated brine and was dried over anhydrous sodium sulfate. The solvent was removed therefrom by distillation under the reduced pressure, and the residue was purified by column chromatography on silica gel using acetone-chloroform to give the title compound (1.83 g, yield 82%).

1. temperatureThe reaction solution was cooled to room temperature
2. extractionThe mixture was extracted with ethyl acetate
3. washThe ethyl acetate layer was then washed with aqueous sodium hydroxide solution and saturated brine
4. dry with materialwas dried over anhydrous sodium sulfate
5. customThe solvent was removed
6. distillationby distillation under the reduced pressure
7. customthe residue was purified by column chromatography on silica gel