Hydrochloride methanol → HCID 23078607, compound

HRID 228511Notes

Reaction equation

HRID 228511 reaction equation
[CH3:1][C:2]1[CH:22]=[C:21]([CH3:23])[CH:20]=[CH:19][C:3]=1[O:4][C:5]1[C:14]2[C:9](=[CH:10][C:11]([O:17][CH3:18])=[C:12]([O:15][CH3:16])[CH:13]=2)[N:8]=[CH:7][CH:6]=1.[ClH:24].CO>>[ClH:24].[CH3:16][O:15][C:12]1[CH:13]=[C:14]2[C:9](=[CH:10][C:11]=1[O:17][CH3:18])[N:8]=[CH:7][CH:6]=[C:5]2[O:4][C:3]1[CH:19]=[CH:20][C:21]([CH3:23])=[CH:22][C:2]=1[CH3:1]

Participants

3

Reactant 2

HCID 21893726Hydrochloride methanolHCID 230782534-(2,4-Dimethylphenoxy)-6,7-dimethoxyquinoline

Product 1

HCID 23078607HCID 23078607, compoundYield 85%

Procedure

4-(2,4-Dimethylphenoxy)-6,7-dimethoxyquinoline (99 mg) was dissolved in a 10% hydrochloric acid/methanol solution, and the solution was stirred at room temperature for 15 min. The solvent was removed therefrom by distillation under the reduced pressure, and the residue was washed with ethyl acetate to give the title compound (94 mg, yield 85%).

Workup

  1. customThe solvent was removed
  2. distillationby distillation under the reduced pressure
  3. washthe residue was washed with ethyl acetate

Sources & evidence

ORD record
ord-f137a51d6c564a2f84dddce0cd7ba159
Source dataset
uspto-grants-2009_07
Patent number
US07560558B2

Reaction notes

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