Hydrochloride methanol → 6,7-Dimethoxy-4-(3,4-dimethylphenoxy)quinoline hydrochloride

HRID 228524Notes

Reaction equation

HRID 228524 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[N:9]=[CH:8][CH:7]=[C:6]2[O:15][C:16]1[CH:21]=[CH:20][C:19]([CH3:22])=[C:18]([CH3:23])[CH:17]=1.[ClH:24].CO>>[ClH:24].[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[N:9]=[CH:8][CH:7]=[C:6]2[O:15][C:16]1[CH:21]=[CH:20][C:19]([CH3:22])=[C:18]([CH3:23])[CH:17]=1

Participants

3

Reactant 2

HCID 21893726Hydrochloride methanolHCID 230783876,7-Dimethoxy-4-(3,4-dimethylphenoxy)quinoline

Product 1

HCID 230785456,7-Dimethoxy-4-(3,4-dimethylphenoxy)quinoline hydrochlorideYield 87%

Procedure

6,7-Dimethoxy-4-(3,4-dimethylphenoxy)quinoline (122 mg) was dissolved in a 10% hydrochloric acid/methanol solution, and the solution was stirred at room temperature for 15 min. The solvent was removed therefrom by distillation under the reduced pressure. The residue was washed with ethyl acetate to give the title compound (118 mg, yield 87%).

Workup

  1. customThe solvent was removed
  2. distillationby distillation under the reduced pressure
  3. washThe residue was washed with ethyl acetate

Sources & evidence

ORD record
ord-d4b6650a7ad546d89649f5741e9d45db
Source dataset
uspto-grants-2009_07
Patent number
US07560558B2

Reaction notes

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