反应详情

4-Chloro-6,7-dimethoxyquinoline (200 mg) and 5-hydroxy-2-nitrobenzaldehyde (299 mg) were suspended in chlorobenzene (2 ml), and the suspension was heated under reflux for 8 hr. The reaction solution was cooled to room temperature, water was then added to the reaction solution, and the mixture was extracted with ethyl acetate. The ethyl acetate layer was then washed with water and saturated brine and was dried over anhydrous sodium sulfate. The solvent was removed therefrom by distillation under the reduced pressure, and the residue was purified by thin layer chromatography using ethyl acetate-hexane to give 3-[(6,7-dimethoxy-4-quinolyl)oxy]-6-nitrobenzaldehyde (210 mg, yield 66%).

1. temperaturethe suspension was heated
2. temperatureunder reflux for 8 hr
3. extractionthe mixture was extracted with ethyl acetate
4. washThe ethyl acetate layer was then washed with water and saturated brine
5. dry with materialwas dried over anhydrous sodium sulfate
6. customThe solvent was removed
7. distillationby distillation under the reduced pressure
8. customthe residue was purified by thin layer chromatography