HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 228536Generated: October 30, 2026
6-Hydroxyquinoline → 6,7-Dimethoxy-4-(6-quinolyloxy)quinoline
https://huagongshe.com/reaction/228536
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 6-Hydroxyquinoline | HCID 11374 | — |
| Reactant | 4-Chloro-6,7-dimethoxyquinoline | HCID 459610 | — |
| Product | 6,7-Dimethoxy-4-(6-quinolyloxy)quinoline | HCID 22132627 | 46.4% |
Reaction Steps
A mixture of 4-chloro-6,7-dimethoxyquinoline (90 mg) with 6-hydroxyquinoline (176 mg) was stirred at 180° C. for 30 min. The reaction solution was cooled to room temperature, and was then purified by column chromatography on silica gel using acetone-hexane to give the title compound (62 mg, yield 46%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07560558B2 |
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| Source dataset | uspto-grants-2009_07 |
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| ORD ID | ord-a35b5a1a04ef473585ca0debf1347b3a |
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| Source note | uspto-grants-2009_07 |
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