Water → HCID 70269420, compound

HRID 2285514Notes

Reaction equation

HRID 2285514 reaction equation
[Cl:1][C:2]1[C:7]([C:8]2[N:9](C(=O)C)[CH2:10][CH2:11][N:12]=2)=[C:6](Cl)[N:5]([NH2:17])[CH:4]([CH3:18])[N:3]=1.[CH3:19][O-:20].[Na+].O>CO>[Cl:1][C:2]1[C:7]([C:8]2[NH:9][CH2:10][CH2:11][N:12]=2)=[C:6]([O:20][CH3:19])[N:5]([NH2:17])[CH:4]([CH3:18])[N:3]=1

Participants

5

Reactant 3

HCID 962WaterHCID 10942334Sodium MethoxideHCID 67367667HCID 67367667, compound

Product 1

HCID 70269420HCID 70269420, compoundYield 85.7%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

10 g 4,6-dichloro-2-methyl-5-(1-acetyl-2-imidazolin-2-yl)-aminopyrimidine are mixed with a solution of 3.78 g sodium methylate in 35 ml methanol and boiled for 2 hours. Then 100 ml water are added, cooled, and vacuum dried. 7.2 g of 4-chloro-6-methoxy-2-methyl-5-(2-imidazolin-2-yl)-aminopyrimidine is obtained. (Melting point 217°-219° C., decomposition) from nitromethane.

Workup

  1. temperaturecooled
  2. customvacuum dried

Sources & evidence

ORD record
ord-1e17c70da0e2443cb0010a2a7db7e7c5
Source dataset
uspto-grants-1982_04
Patent number
US04323570

Reaction notes

Loading…