Sodium Methoxide → HCID 70546260, compound

HRID 2285515Notes

Reaction equation

HRID 2285515 reaction equation
Cl[C:2]1[C:7]([C:8]2[NH:9][CH2:10][CH2:11][N:12]=2)=[C:6]([S:13][CH3:14])[N:5]([NH2:15])[CH:4]([CH3:16])[N:3]=1.[CH3:17][O-:18].[Na+]>>[CH3:17][O:18][C:2]1[C:7]([C:8]2[NH:9][CH2:10][CH2:11][N:12]=2)=[C:6]([S:13][CH3:14])[N:5]([NH2:15])[CH:4]([CH3:16])[N:3]=1

Participants

3

Reactant 2

HCID 10942334Sodium MethoxideHCID 70547082HCID 70547082, compound

Product 1

HCID 70546260HCID 70546260, compound

Procedure

3 g 4-chloro-2-methyl-6-methylthio-5-(2-imidazolin-2-yl)-aminopyrimidine (Example 2) are mixed with 60 ml 15% methanolic sodium methylate solution and boiled for 4 hours under reflux. Then about 40 ml methanol are distilled off. The solution is mixed with water and cooled until it crystallizes. 1.5 g of 4-methoxy-2-methyl-6-methylthio-5-(2-imidazolin-2-yl)-aminopyrimidine is obtained, (Melting point 267° C.) after recrystallization from nitromethane.

Workup

  1. temperatureunder reflux
  2. distillationThen about 40 ml methanol are distilled off
  3. additionThe solution is mixed with water
  4. temperaturecooled until it
  5. customcrystallizes

Sources & evidence

ORD record
ord-a1ef8f995cc04b1e80fef167f78c80e1
Source dataset
uspto-grants-1982_04
Patent number
US04323570

Reaction notes

Loading…