Methanol → HCID 70545608, compound

HRID 2285517Notes

Reaction equation

HRID 2285517 reaction equation
[CH:1]1([CH:4]2[N:9]=[C:8](Cl)[C:7]([C:11]3[N:12](C(=O)C)[CH2:13][CH2:14][N:15]=3)=[C:6](Cl)[N:5]2[NH2:20])[CH2:3][CH2:2]1.[CH3:21][O-:22].[Na+].[CH3:24][OH:25]>>[CH:1]1([CH:4]2[N:9]=[C:8]([O:22][CH3:21])[C:7]([C:11]3[NH:12][CH2:13][CH2:14][N:15]=3)=[C:6]([O:25][CH3:24])[N:5]2[NH2:20])[CH2:2][CH2:3]1

Participants

4

Reactant 3

HCID 887MethanolHCID 10942334Sodium MethoxideHCID 70546625HCID 70546625, compound

Product 1

HCID 70545608HCID 70545608, compound

Procedure

3.0 g 2-cyclopropyl-4,6-dichloro-5-(1-acetyl-2-imidazolin-2-yl)-aminopyrimidine are mixed with a solution of 1.4 g sodium methylate in 15 ml methanol and heated for 6 hours under reflux. The solution then is concentrated, mixed with water, and extracted with chloroform. The chlorform phase is dried and concentrated. 1.8 g of 2-cyclopropyl-4,6-dimethoxy-5(2-imidazolin-2-yl)-aminopyrimidine (melting point 193°-195° C.) is obtained. The hydrochloride of this compound melts at 214°-216° C.

Workup

  1. temperatureheated for 6 hours
  2. temperatureunder reflux
  3. concentrationThe solution then is concentrated
  4. additionmixed with water
  5. extractionextracted with chloroform
  6. dry with materialThe chlorform phase is dried
  7. concentrationconcentrated

Sources & evidence

ORD record
ord-7e32b2515d0e410c9ee0bb27e583dc27
Source dataset
uspto-grants-1982_04
Patent number
US04323570

Reaction notes

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