Methanol → HCID 70545608, compound

Participants

Reaction Steps

3.0 g 2-cyclopropyl-4,6-dichloro-5-(1-acetyl-2-imidazolin-2-yl)-aminopyrimidine are mixed with a solution of 1.4 g sodium methylate in 15 ml methanol and heated for 6 hours under reflux. The solution then is concentrated, mixed with water, and extracted with chloroform. The chlorform phase is dried and concentrated. 1.8 g of 2-cyclopropyl-4,6-dimethoxy-5(2-imidazolin-2-yl)-aminopyrimidine (melting point 193°-195° C.) is obtained. The hydrochloride of this compound melts at 214°-216° C.

Provenance & Evidence