Nitric Acid → HCID 178526880, compound

HRID 2285518Notes

Reaction equation

HRID 2285518 reaction equation
[N+:1]([O-:4])(O)=[O:2].[CH:5]1([C:8]2[N:13]=[C:12]([OH:14])[CH:11]=[C:10]([OH:15])[N:9]=2)[CH2:7][CH2:6]1>C(O)(=O)C>[CH:5]1([C:8]2[N:13]=[C:12]([OH:14])[C:11]([N+:1]([O-:4])=[O:2])=[C:10]([OH:15])[N:9]=2)[CH2:7][CH2:6]1

Participants

4

Reactant 2

HCID 944Nitric AcidHCID 178516636HCID 178516636, compound

Product 1

HCID 178526880HCID 178526880, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
15 °C

Procedure

To 128.8 ml acetic acid are added 50.57 ml fuming nitric acid without exceeding 20° C. 57 g (0.375 mole) 2-cyclopropyl-4,6-dihydroxy-pyrimidine are added in portions without exceeding a temperature of 15° C. Then the reaction mixture is stirred for half an hour at 15° C., mixed with ice, and the deposit is washed with lots of water and dried. 69.8 of 2-cyclopropyl-4,6-dihydroxy-5-nitro-pyrimidine is obtained. Melting point 230°-235° C. (decomp.).

Workup

  1. customwithout exceeding 20° C
  2. customa temperature of 15° C
  3. additionmixed with ice
  4. washthe deposit is washed with lots of water
  5. customdried

Sources & evidence

ORD record
ord-4e043d614b374ad6b0c8a3232cb7761c
Source dataset
uspto-grants-1982_04
Patent number
US04323570

Reaction notes

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