Ethanol → HCID 70545394, compound

Participants

Reaction Steps

3.0 g 4,6-dichloro-2-methyl-5-(1-acetyl-2-imidazolin-2-yl)-aminopyrimidine are introduced at room temperature into a solution of 0.5 g sodium in 10 ml ethanol. Subsequently, the solution is heated for 30 minutes to 75° C., filtered, the filtrate is concentrated, the residue is placed in ice water, and the crystals are vacuum dried. After recrystallization from nitromethane, 1.2 g (45%) of 4-chloro-6-ethoxy-2-methyl-5-(2-imidazolin-2-yl)-aminopyrimidine, melting point 221° C., is obtained.

Provenance & Evidence