Ethanol → HCID 70545394, compound

HRID 2285521Notes

Reaction equation

HRID 2285521 reaction equation
[Cl:1][C:2]1[C:7]([C:8]2[N:9](C(=O)C)[CH2:10][CH2:11][N:12]=2)=[C:6](Cl)[N:5]([NH2:17])[CH:4]([CH3:18])[N:3]=1.[Na].[CH2:20]([OH:22])[CH3:21]>>[Cl:1][C:2]1[C:7]([C:8]2[NH:9][CH2:10][CH2:11][N:12]=2)=[C:6]([O:22][CH2:20][CH3:21])[N:5]([NH2:17])[CH:4]([CH3:18])[N:3]=1

Participants

4

Reactant 3

HCID 702EthanolHCID 5360545SodiumHCID 67367667HCID 67367667, compound

Product 1

HCID 70545394HCID 70545394, compound

Procedure

3.0 g 4,6-dichloro-2-methyl-5-(1-acetyl-2-imidazolin-2-yl)-aminopyrimidine are introduced at room temperature into a solution of 0.5 g sodium in 10 ml ethanol. Subsequently, the solution is heated for 30 minutes to 75° C., filtered, the filtrate is concentrated, the residue is placed in ice water, and the crystals are vacuum dried. After recrystallization from nitromethane, 1.2 g (45%) of 4-chloro-6-ethoxy-2-methyl-5-(2-imidazolin-2-yl)-aminopyrimidine, melting point 221° C., is obtained.

Workup

  1. temperatureSubsequently, the solution is heated for 30 minutes to 75° C.
  2. filtrationfiltered
  3. concentrationthe filtrate is concentrated
  4. customdried
  5. customAfter recrystallization from nitromethane, 1.2 g (45%) of 4-chloro-6-ethoxy-2-methyl-5-(2-imidazolin-2-yl)-aminopyrimidine, melting point 221° C.
  6. customis obtained

Sources & evidence

ORD record
ord-f41a55a7ea7e408b82cfc2fcd4eec73e
Source dataset
uspto-grants-1982_04
Patent number
US04323570

Reaction notes

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