HCID 57319743, compound → HCID 57185699, compound

HRID 2285522Notes

Reaction equation

HRID 2285522 reaction equation
[Cl:1][C:2]1[C:7]([C:8]2[N:9](C(=O)C)[CH2:10][CH2:11][N:12]=2)=[C:6]([Cl:16])[N:5]=[C:4]([NH2:17])[N:3]=1>C(O)(=O)C>[Cl:16][C:6]1[C:7]([C:8]2[NH:9][CH2:10][CH2:11][N:12]=2)=[C:2]([Cl:1])[N:3]=[C:4]([NH2:17])[N:5]=1

Participants

3

Reactant 1

HCID 57319743HCID 57319743, compound

Product 1

HCID 57185699HCID 57185699, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

4.0 g 4,6-dichloro-5-(1-acetyl-2-imidazolin-2-yl)-aminopyrimidine are kept in 80 ml 50% acetic acid for 2 days at 60° C. Then the solution is concentrated, the residue taken up in water and extracted with chloroform, whereby the starting material and the byproducts are separated. Subsequently, the aqueous phase is alkalized, and the reaction product is extracted with chloroform. After concentration, 1.4 g (41%) 4,6-dichloro-5-(2-imidazolin-2-yl)-aminopyrimidine, melting point 197°-198° C., is obtained.

Workup

  1. concentrationThen the solution is concentrated
  2. extractionextracted with chloroform, whereby the starting material
  3. customthe byproducts are separated
  4. extractionthe reaction product is extracted with chloroform
  5. concentrationAfter concentration, 1.4 g (41%) 4,6-dichloro-5-(2-imidazolin-2-yl)-aminopyrimidine, melting point 197°-198° C.
  6. customis obtained

Sources & evidence

ORD record
ord-3b6ac1c91ee34eed8024ee053caddd8a
Source dataset
uspto-grants-1982_04
Patent number
US04323570

Reaction notes

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