HCID 57319743, compound → HCID 57185699, compound

Participants

Reaction Steps

4.0 g 4,6-dichloro-5-(1-acetyl-2-imidazolin-2-yl)-aminopyrimidine are kept in 80 ml 50% acetic acid for 2 days at 60° C. Then the solution is concentrated, the residue taken up in water and extracted with chloroform, whereby the starting material and the byproducts are separated. Subsequently, the aqueous phase is alkalized, and the reaction product is extracted with chloroform. After concentration, 1.4 g (41%) 4,6-dichloro-5-(2-imidazolin-2-yl)-aminopyrimidine, melting point 197°-198° C., is obtained.

Provenance & Evidence