4-Toluenesulfonyl chloride → HCID 20544870, compound

HRID 2285529Notes

Reaction equation

HRID 2285529 reaction equation
[CH3:1][N:2]1[C:6]([NH:7][CH2:8][CH2:9][CH2:10][O:11][C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([CH2:18][N:19]3[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]3)[CH:13]=2)=[N:5][C:4]([NH2:25])=[N:3]1.CC1C=CC(S(Cl)(=O)=[O:34])=CC=1.CC1C=CC(S(NC2N=C(NCCC[O:57][C:58]3C=[CH:62][CH:61]=[C:60](CN4CCCCC4)[CH:59]=3)N(C)N=2)(=O)=O)=CC=1>>[CH3:1][N:2]1[C:6]([NH:7][CH2:8][CH2:9][CH2:10][O:11][C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([CH2:18][N:19]3[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]3)[CH:13]=2)=[N:5][C:4]([NH:25][C:62]([C:61]2[O:57][CH:58]=[CH:59][CH:60]=2)=[O:34])=[N:3]1

Participants

4

Reactant 3

HCID 73974-Toluenesulfonyl chlorideHCID 71988LamtidineHCID 20544849HCID 20544849, compound

Product 1

HCID 20544870HCID 20544870, compound

Procedure

The triazole (A) (2.00 g) and 4-methylbenzenesulphonic acid, chloride (1.22 g) was 4-methyl-N-[1-methyl-5-[[3-[3-(1-piperidinylmethyl)phenoxy]propyl]amino]-1H-1,2,4-triazol-3-yl]benzenesulphonamide (1.58 g) m.p. 100.5°-102°.

Sources & evidence

ORD record
ord-59aa50d9af0e4806bbabf1cfd95d8676
Source dataset
uspto-grants-1982_04
Patent number
US04323566

Reaction notes

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