Methyl Isocyanate → HCID 20544862, compound

HRID 2285530Notes

Reaction equation

HRID 2285530 reaction equation
[CH3:1][N:2]1[C:6]([NH:7][CH2:8][CH2:9][CH2:10][O:11][C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([CH2:18][N:19]3[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]3)[CH:13]=2)=[N:5][C:4]([NH2:25])=[N:3]1.[CH3:26][N:27]=[C:28]=[O:29]>C(#N)C>[CH3:26][NH:27][C:28]([NH:25][C:4]1[N:5]=[C:6]([NH:7][CH2:8][CH2:9][CH2:10][O:11][C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([CH2:18][N:19]3[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]3)[CH:13]=2)[N:2]([CH3:1])[N:3]=1)=[O:29]

Participants

4

Reactant 2

HCID 12228Methyl IsocyanateHCID 71988Lamtidine

Product 1

HCID 20544862HCID 20544862, compoundYield 81.5%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A mixture of 1-methyl-N5 -[3-[3-(1-piperidinylmethyl)phenoxy]propyl]-1H-1,2,4-triazole-3,5-diamine (2.00 g) and methylisocyanate (1.2 g) in dry acetonitrile (60 ml) was heated at reflux for 2 h. and allowed to cool. The precipitated solid was collected and recrystallised from methanol to give the title compound (1.9 g).

Workup

  1. temperaturewas heated
  2. temperatureat reflux for 2 h.
  3. temperatureto cool
  4. customThe precipitated solid was collected
  5. customrecrystallised from methanol

Sources & evidence

ORD record
ord-b5fd61ec0c4e4e269dcb8ca00b36a43d
Source dataset
uspto-grants-1982_04
Patent number
US04323566

Reaction notes

Loading…