Triethylamine → HCID 12928950, compound

HRID 2285601Notes

Reaction equation

HRID 2285601 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=[CH:4][N:3]=1.C(N(CC)CC)C.[Br:19][C:20]1[CH:25]=[CH:24][C:23]([S:26][CH2:27][CH2:28][NH2:29])=[CH:22][CH:21]=1>C1C=CC=CC=1>[Br:19][C:20]1[CH:21]=[CH:22][C:23]([S:26][CH2:27][CH2:28][NH:29][C:2]2[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[N:5]=[CH:4][N:3]=2)=[CH:24][CH:25]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 788644-ChloroquinazolineHCID 42061569326-62-1

Product 1

HCID 12928950HCID 12928950, compoundYield 55.5%

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

To a solution of 2.5 g (0.015 mol) of 4-chloroquinazoline in 50 ml of benzene were added 1.5 g (0.015 mol) of triethylamine and 3.5 g (0.015 mol) of 2-(p-bromophenylthio) ethylamine, and the mixture was heated, with stirring, at 70°~80° C. for 3 hours. After completion of the reaction, the benzene was evaporated under reduced pressure and the resulting crystals were washed with water, collected by filtration and recrystallized from ethanol, giving 3.0 g of 4-[2-(4-bromophenylthio)ethyl]aminoquinazoline in the form of colorless granules.

Workup

  1. temperaturethe mixture was heated
  2. customAfter completion of the reaction
  3. customthe benzene was evaporated under reduced pressure
  4. washthe resulting crystals were washed with water
  5. filtrationcollected by filtration
  6. customrecrystallized from ethanol

Sources & evidence

ORD record
ord-ca3be70c0d4c4cd0b9aa4cf876ba67f1
Source dataset
uspto-grants-1982_04
Patent number
US04323680

Reaction notes

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