反应详情

温度

0 °C

5-Chloro-2-[(6,7-dimethoxy-4-quinolyl)oxy]benzaldehyde was dissolved in anhydrous tetrahydrofuran (1 ml) to prepare a solution. A 1 M tetrahydrofuran solution (0.5 ml) of ethylmagnesium bromide was added to the solution at 0° C., and the mixture was stirred at 0° C. for one hr. Water (1 ml) was added dropwise to the reaction solution to stop the reaction. The mixture was extracted with ethyl acetate, and the ethyl acetate layer was then washed with water and saturated brine and was dried over anhydrous sodium sulfate. The solvent was removed by distillation under the reduced pressure to give 1-{5-chloro-2-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}-1-propanol.

1. customto prepare a solution
2. customthe reaction
3. extractionThe mixture was extracted with ethyl acetate
4. washthe ethyl acetate layer was then washed with water and saturated brine
5. dry with materialwas dried over anhydrous sodium sulfate
6. customThe solvent was removed by distillation under the reduced pressure