Hydrochloric Acid → 2,4-Diaminophenol
Reaction equation
[N+:1]([C:4]1[CH:9]=[C:8]([N+:10]([O-])=O)[CH:7]=[CH:6][C:5]=1[OH:13])([O-])=O.Cl.[H][H]>>[NH2:1][C:4]1[CH:9]=[C:8]([NH2:10])[CH:7]=[CH:6][C:5]=1[OH:13]Participants
Conditions
- Temperature
- 150 °C
Procedure
Into the reactor described in Example 6 there are placed 30 g of 2,4-dinitrophenol and 30 ml of a 37% aqueous solution of hydrochloric acid. The resulting suspension is thoroughly intermixed. The reactor is then hermetically closed with a cover, whereinto a thin-wall coiled tube is soldered. Hydrogen is continuously admitted into the tube under the pressure of 60 atm at the rate of 25 ml/min. The reactor is heated to the temperature of 150° C. and pressure therein over the suspension is increased to 60 atm. Under these conditions hydrogenation is carried out for 4 hours. After cooling and precipitation with a 37% hydrochloric acid the resulting product is filtered-off and washed with methanol to give 24 g of 2,4-diaminophenol which corresponds to 77% as calculated for the starting 2,4-dinitrophenol.
Workup
- customThe reactor is then hermetically closed with a cover, whereinto a thin-wall coiled tube
- temperatureover the suspension is increased to 60 atm
- temperatureAfter cooling
- customprecipitation with a 37% hydrochloric acid the resulting product
- washwashed with methanol
Sources & evidence
- ORD record
- ord-27d54873e90b454d9037eeb071529157
- Source dataset
- uspto-grants-1982_04
- Patent number
- US04323708
Reaction notes
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