Pyridinium chloride → 4-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)oxyphenol

HRID 2285650Notes

Reaction equation

HRID 2285650 reaction equation
[Cl:1][C:2]1[C:3]([O:12][C:13]2[CH:18]=[CH:17][C:16]([O:19]C)=[CH:15][CH:14]=2)=[N:4][CH:5]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:7]=1.Cl.N1C=CC=CC=1>Cl>[Cl:1][C:2]1[C:3]([O:12][C:13]2[CH:18]=[CH:17][C:16]([OH:19])=[CH:15][CH:14]=2)=[N:4][CH:5]=[C:6]([C:8]([F:11])([F:9])[F:10])[CH:7]=1

Participants

4

Reactant 2

HCID 10176127Pyridinium chlorideHCID 199860193-Chloro-2-p-methoxyphenoxy-5-trifluoromethylpyridine

Product 1

HCID 97959974-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)oxyphenol

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

The product from (e) (2 g) was heated with pyridine hydrochloride (20 g) at 170°-180° C. for 6 hours. The mixture was cooled, diluted with dilute hydrochloric acid, and extracted with ether. The ether extracts gave an oily solid which was purified by preparative thin layer chromatography using silica as the adsorbent and 6% ethanol-chloroform as the solvent.

Workup

  1. temperatureThe mixture was cooled
  2. extractionextracted with ether
  3. customThe ether extracts gave an oily solid which
  4. customwas purified by preparative thin layer chromatography

Sources & evidence

ORD record
ord-6b65c21783af4f5c86bce40b90134151
Source dataset
uspto-grants-1982_04
Patent number
US04324627

Reaction notes

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