Methyl chloroformate → HCID 20544054, compound

HRID 2285702Notes

Reaction equation

HRID 2285702 reaction equation
[OH:1][C:2]1[NH:3][NH:4][C:5]2[CH:11]=[CH:10][CH:9]=[N:8][C:6]=2[N:7]=1.[Cl:12][C:13]([O:15][CH3:16])=[O:14]>O1CCOCC1>[ClH:12].[CH3:16][O:15][C:13]([N:4]1[C:5]2[CH:11]=[CH:10][CH:9]=[N:8][C:6]=2[N:7]=[C:2]([O:1][C:13]([O:15][CH3:16])=[O:14])[NH:3]1)=[O:14]

Participants

4

Reactant 2

HCID 6586Methyl chloroformateHCID 178517375HCID 178517375, compound

Product 1

HCID 20544054HCID 20544054, compoundYield 79%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A mixture of 2.5 g (0.015 moles) of 3-hydroxy-1,2-dihydro-pyrido[2,3-e]-as-triazine, 2.16 g (0.03 moles) of methyl chloroformate and 100 ml of dioxane is maintained at 5°-10° C. for 3 hours and then at 40°-50° C. for 5 hours. Thereafter the solvent is removed to obtain 3.58 g (79%) of the title compound; m.p.: 159°-160° C.

Workup

  1. temperatureis maintained at 5°-10° C. for 3 hours
  2. customThereafter the solvent is removed

Sources & evidence

ORD record
ord-5a73a21639bb48ebad79c0051e865b23
Source dataset
uspto-grants-1982_04
Patent number
US04324786

Reaction notes

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