2,6-Pyridinedimethanamine → HCID 70545036, compound

HRID 2285711Notes

Reaction equation

HRID 2285711 reaction equation
[O:1]=[C:2]1[CH2:6][CH2:5][CH2:4][N:3]1[CH2:7][C:8]([O:10]C1C=C(Cl)C(Cl)=CC=1Cl)=O.[NH2:20][CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[C:24]([CH2:28][NH2:29])[N:23]=1>CN(C)C=O>[O:1]=[C:2]1[CH2:6][CH2:5][CH2:4][N:3]1[CH2:7][C:8]([NH:20][CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[C:24]([CH2:28][NH:29][C:8](=[O:10])[CH2:7][N:3]2[CH2:4][CH2:5][CH2:6][C:2]2=[O:1])[N:23]=1)=[O:10]

Participants

4

Reactant 2

HCID 137237542,6-PyridinedimethanamineHCID 20544060HCID 20544060, compound

Product 1

HCID 70545036HCID 70545036, compoundYield 57%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent2×

Conditions

Temperature
60 °C

Procedure

0.02 mol of 2,4,5-trichlorophenyl 2-oxo-pyrrolidineacetate is dissolved in 50 ml of dimethylformamide and reacted with a solution of 0.01 mol of 2,6-diaminomethylpyridine in 20 ml of dimethylformamide, at -5° C., whilst stirring and with the exclusion of moisture. After leaving the reaction solution to stand at room temperature for three hours, it is warmed to 60° C. for 2 hours, the solvent is then evaporated off, ether is added to the residue and the crystals which precipitate are filtered off. Melting point: 149° C., yield 57% of theory

Workup

  1. customAfter leaving the reaction solution
  2. customthe solvent is then evaporated off
  3. additionether is added to the residue
  4. filtrationthe crystals which precipitate are filtered off

Sources & evidence

ORD record
ord-50e5dd8310a0402e81334b983cd7ea69
Source dataset
uspto-grants-1982_04
Patent number
US04324787

Reaction notes

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