Hydrochloric Acid → HCID 3066248, compound

HRID 2285724Notes

Reaction equation

HRID 2285724 reaction equation
Cl.O1CCCCC1[O:8][CH2:9][CH2:10][N:11]1[CH2:16][CH:15]=[C:14]([C:17]2[C:25]3[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=3)[NH:19][CH:18]=2)[CH2:13][CH2:12]1.C(O)C.[OH-].[Na+]>O>[NH:19]1[C:20]2[C:25](=[CH:24][CH:23]=[CH:22][CH:21]=2)[C:17]([C:14]2[CH2:15][CH2:16][N:11]([CH2:10][CH2:9][OH:8])[CH2:12][CH:13]=2)=[CH:18]1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 14798Sodium HydroxideHCID 13019592HCID 13019592, compound

Product 1

HCID 3066248HCID 3066248, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

15.6 ml of 6 N hydrochloric acid were added to a mixture of the product of Step A and 156 ml of 95% ethanol and the mixture was stirred for 31/2 hours under an inert atmosphere and was then poured into one liter of water. 10 ml of sodium hydroxide were added to the mixture which was then filtered. The recovered crystals were washed with water and dried under reduced pressure to obtain 4.068 g of 4-(1H-indol-3-yl)-3,6-dihydro-1-(2H)-pyridine-ethanol melting at 164°-165° C.

Workup

  1. filtrationwas then filtered
  2. washThe recovered crystals were washed with water
  3. customdried under reduced pressure

Sources & evidence

ORD record
ord-b9dce8bb4ab34088a84aa7f55d5e9b77
Source dataset
uspto-grants-1982_04
Patent number
US04324790

Reaction notes

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