Acetonitrile → HCID 178491309, compound

Participants

Reaction Steps

Anisoyl chloride (4.3 ml) was added slowly to a stirred solution of 1-benzylimidazole (5.0 g) in dry acetonitrile (50 ml) keeping the temperature at 25°-30°. After stirring for 1 h. triethylamine (4.4 ml) was added dropwise and the mixture stirred for 18 h. then filtered. The filtrate was concentrated to dryness, and the residue taken up into ether (100 ml) and washed with acetic acid (25%, 3×50 ml), and 2 N sodium carbonate (3×50 ml), then concentrated until the title compound crystallised as a white solid, m.p. 108°-110° (3.1 g).

Provenance & Evidence