Nicotinamide → 5469-10-3

HRID 2285764Notes

Reaction equation

HRID 2285764 reaction equation
[CH2:1]([Br:10])[C:2]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)=[O:3].[C:11]([NH2:19])(=[O:18])[C:12]1[CH:17]=[CH:16][CH:15]=[N:14][CH:13]=1>CC(C)=O>[Br-:10].[C:11]([C:12]1[CH:13]=[N+:14]([CH2:1][C:2]([C:4]2[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=2)=[O:3])[CH:15]=[CH:16][CH:17]=1)(=[O:18])[NH2:19]

Participants

4

Reactant 2

HCID 936NicotinamideHCID 6259Phenacyl bromide

Product 1

HCID 121189185469-10-3

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

17.5 g of phenacyl bromide was dissolved in 16 ml of acetone combined with a hot solution prepared by dissolving 10.73 g of nicotinamide in 24 ml of alcohol, and heated for 5 minutes on a steam bath. After cooling, crystals thus formed were collected by filtration and washed with alcohol and benzene to obtain 15.5 g of slightly yellow crystals (3-carbamoyl-1-phenacylpyridinium bromide).

Workup

  1. customprepared
  2. temperatureheated for 5 minutes on a steam bath
  3. temperatureAfter cooling
  4. customcrystals thus formed
  5. filtrationwere collected by filtration
  6. washwashed with alcohol and benzene

Sources & evidence

ORD record
ord-cc3be0cc958e486dbbd9be832e012b66
Source dataset
uspto-grants-1982_04
Patent number
US04324855

Reaction notes

Loading…