Hydrochloric Acid → HCID 20544472, compound

HRID 2285846Notes

Reaction equation

HRID 2285846 reaction equation
[O:1]=[C:2]1[CH:7]=[C:6]([CH3:8])[O:5][CH:4]=[C:3]1[O:9][CH2:10][C:11]([O:13]CC)=[O:12].Cl>[OH-].[Na+]>[O:1]=[C:2]1[CH:7]=[C:6]([CH3:8])[O:5][CH:4]=[C:3]1[O:9][CH2:10][C:11]([OH:13])=[O:12]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 20544441HCID 20544441, compound

Product 1

HCID 20544472HCID 20544472, compoundYield 94.4%

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent2×

Procedure

A mixture of ethyl 2-(4-oxo-6-methyl-4H-pyran-3-yloxy)acetate (8.3 g) in 1 N sodium hydroxide (40 ml) was stirred at room temperature for 30 minutes. To the mixture was added further 1 N sodium hydroxide (6 ml) and the resultant mixture was stirred for 30 minutes. To the reaction mixture was added dropwise conc. hydrochloric acid (4 ml) under ice-cooling, and resulting crystals were collected by filtration, washed with water, and dried to give crystals (6.8 g) of 2-(4-oxo-6-methyl-4H-pyran-3-yloxy)acetic acid.

Workup

  1. temperaturecooling
  2. customresulting crystals
  3. filtrationwere collected by filtration
  4. washwashed with water
  5. customdried

Sources & evidence

ORD record
ord-a3df1279c9334d2cb7a22a19a4141b74
Source dataset
uspto-grants-1982_04
Patent number
US04324892

Reaction notes

Loading…