HCID 15571201, compound → HCID 20542628, compound

HRID 2285894Notes

Reaction equation

HRID 2285894 reaction equation
[BrH:1].[F:2][C:3]1[CH:26]=[CH:25][CH:24]=[CH:23][C:4]=1[CH:5]([C:13]1(O)[N:17]2[CH2:18][CH2:19][CH2:20][N:21]=[C:16]2[S:15][CH2:14]1)[C:6]1[CH:11]=[CH:10][C:9]([F:12])=[CH:8][CH:7]=1>CC(C)=O>[BrH:1].[F:2][C:3]1[CH:26]=[CH:25][CH:24]=[CH:23][C:4]=1[CH:5]([C:13]1[N:17]2[CH2:18][CH2:19][CH2:20][N:21]=[C:16]2[S:15][CH:14]=1)[C:6]1[CH:7]=[CH:8][C:9]([F:12])=[CH:10][CH:11]=1

Participants

3

Reactant 1

HCID 15571201HCID 15571201, compound

Product 1

HCID 20542628HCID 20542628, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

A test tube containing 1.0 g. of 3-[o-fluoro-α-(p-fluorophenyl)benzyl]-2,3,6,7-tetrahydro-5H-thiazolo[3,2-a]pyrimidine-3-ol hydrobromide is immersed in an oil bath at 215° C. for 20 minutes. The compound decomposes, becomes liquid and then rehardens. A 5 ml. portion of acetone is added and the mixture is stirred and filtered. The crystalline product is washed with acetone and dried in vacuo, giving the desired product, m.p. 291°-293° C.

Workup

  1. additionA test tube containing 1.0 g
  2. filtrationfiltered
  3. washThe crystalline product is washed with acetone
  4. customdried in vacuo

Sources & evidence

ORD record
ord-31c390136cb143d480b335cd822f512b
Source dataset
uspto-grants-1982_04
Patent number
US04325955

Reaction notes

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