HCID 15571201, compound → HCID 20542628, compound

Participants

Reaction Steps

A test tube containing 1.0 g. of 3-[o-fluoro-α-(p-fluorophenyl)benzyl]-2,3,6,7-tetrahydro-5H-thiazolo[3,2-a]pyrimidine-3-ol hydrobromide is immersed in an oil bath at 215° C. for 20 minutes. The compound decomposes, becomes liquid and then rehardens. A 5 ml. portion of acetone is added and the mixture is stirred and filtered. The crystalline product is washed with acetone and dried in vacuo, giving the desired product, m.p. 291°-293° C.

Provenance & Evidence