反应详情

A solution of 1-methyl-4-phenyl-4-piperidinol (7.65 g, 40 mM) in dry DMSO (100 ml) was treated with sodium hydride (2.0 g of 50% dispersion in oil 42 mM), the mixture stirred for 1 hour and then treated with 2-fluoronitrobenzene (5.65 g, 40 mM). After 24 hours the reaction mixture was poured in to water (500 ml) and extracted with ether (2×500 ml). The organic extract was washed with brine, dried and the solvents removed under reduced pressure. Recrystallisation of the residue from cyclohexane gave the title compound (4.1 g) m.p. 80°-2° C.

1. extractionextracted with ether (2×500 ml)
2. extractionThe organic extract
3. washwas washed with brine
4. customdried
5. customthe solvents removed under reduced pressure
6. customRecrystallisation of the residue from cyclohexane