反应详情

Propargyl p-toluenesulphonate (6.0 g, 0.05 mole) was heated with 2,6-dimethylaniline (6.0 g, 0.05 mole) on steam bath for 2 hours, poured into water (100 ml), extracted into methylenedichloride (50 ml), dried (MgSO4), filtered, solvent evaporated and the product distilled to give 2,6-dimethylphenyl propargylamine, identical with that in Route II. Subsequent preparative steps were as outlined in Route II.

1. extractionextracted into methylenedichloride (50 ml)
2. dry with materialdried (MgSO4)
3. filtrationfiltered
4. customsolvent evaporated
5. distillationthe product distilled