HuagongsheHuagongshe Chemistry Print Report · For research reference only
N,N-Dimethyl-1,3-propanediamine → N-(3'-Dimethylaminopropyl)-aspartic acid-4-isopropyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N,N-Dimethyl-1,3-propanediamine | HCID 7993 | — |
| Reactant | Monoisopropyl maleate | HCID 6436106 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | N-(3'-Dimethylaminopropyl)-aspartic acid-4-isopropyl ester | HCID 54445499 | 94.7% |
Reaction Steps
395.2 g (2.5 mols) of maleic acid-monoisopropyl ester, 500 ml of triethylamine and 306.5 g (2.5 mols+20% excess) of 3-dimethylaminopropylamine are reacted according to Example 1, and the reaction product is subsequently purified to yield 616.4 g (94.7% of theory) of a white crystalline aspartic acid derivative of which the melting point is 163.5°-165.5° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04326069 |
| Source dataset | uspto-grants-1982_04 |
| ORD ID | ord-e352994ac067463fa62996e4163fb7f0 |
| Source note | uspto-grants-1982_04 |