Hydrochloric Acid → HCID 13050370, compound

HRID 2286117Notes

Reaction equation

HRID 2286117 reaction equation
[NH2:1][CH:2]([CH:8]([F:10])[F:9])[CH2:3][CH2:4][C:5]([OH:7])=[O:6].[C:11](Cl)(=[O:13])[CH3:12].Cl>[OH-].[Na+].O1CCOCC1>[F:9][CH:8]([F:10])[CH:2]([NH:1][C:11](=[O:13])[CH3:12])[CH2:3][CH2:4][C:5]([OH:7])=[O:6]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 6367Acetyl chlorideHCID 13050369HCID 13050369, compound

Product 1

HCID 13050370HCID 13050370, compound

Reagents, catalysts & solvents 2

HCID 14798Sodium HydroxideSolvent2×HCID 312751,4-DioxaneSolvent

Procedure

To a solution of 2 mmole of 4-amino-4-difluoromethylbutyric acid in 5 ml of 1 N sodium hydroxide at 0° C. are added simultaneously from two syringes 160 mg of acetyl chloride diluted in 1 ml of dioxane and 2 ml of 1 N sodium hydroxide. After 30 minutes at 0° C. the solution is acidified by the addition of 6 N hydrochloric acid, then extracted well with dichloromethane. The organic phase is dried and concentrated to afford 4-difluoromethyl-4-(1-oxoethylamino)butyric acid.

Workup

  1. extractionextracted well with dichloromethane
  2. customThe organic phase is dried
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-fa71501c84834a4db541dea5edd114ac
Source dataset
uspto-grants-1982_04
Patent number
US04326071

Reaction notes

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