Ethanol → HCID 53893301, compound

HRID 2286119Notes

Reaction equation

HRID 2286119 reaction equation
[NH2:1][CH:2]([CH:8]([F:10])[F:9])[CH2:3][CH2:4][C:5]([OH:7])=[O:6].S(Cl)(Cl)=O.[CH2:15](O)[CH3:16]>ClCCl>[CH2:15]([O:6][C:5](=[O:7])[CH2:4][CH2:3][CH:2]([NH2:1])[CH:8]([F:10])[F:9])[CH3:16]

Participants

5

Reactant 3

HCID 702EthanolHCID 24386Thionyl ChlorideHCID 13050369HCID 13050369, compound

Product 1

HCID 53893301HCID 53893301, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
25 °C

Procedure

A solution of 2 mmole of 4-amino-4-difluoromethylbutyric acid in 15 ml of dichloromethane is treated with 2 mmole of thionyl chloride at 25° C. for one hour after which 20 ml of ethanol is added. The solution is stirred at 25° C. for one hour, washed with water, dried and concentrated to afford 4-amino-4-difluoromethylbutyric acid ethyl ester.

Workup

  1. additionis added
  2. washwashed with water
  3. customdried
  4. concentrationconcentrated

Sources & evidence

ORD record
ord-05eaa20eb3ff4d02972b21dba56209c7
Source dataset
uspto-grants-1982_04
Patent number
US04326071

Reaction notes

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