Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | HCID 13050369 | HCID 13050369 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 53893301 | HCID 53893301 | — |
Reaction Steps
A solution of 2 mmole of 4-amino-4-difluoromethylbutyric acid in 15 ml of dichloromethane is treated with 2 mmole of thionyl chloride at 25° C. for one hour after which 20 ml of ethanol is added. The solution is stirred at 25° C. for one hour, washed with water, dried and concentrated to afford 4-amino-4-difluoromethylbutyric acid ethyl ester.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04326071 |
|---|
| Source dataset | uspto-grants-1982_04 |
|---|
| ORD ID | ord-05eaa20eb3ff4d02972b21dba56209c7 |
|---|
| Source note | uspto-grants-1982_04 |
|---|
