1-(1H-Imidazol-1-yl)ethanone → HCID 12832895, compound

HRID 2286128Notes

Reaction equation

HRID 2286128 reaction equation
[Cl:1][C:2]1[C:3]([C:7]2[CH:12]=[CH:11][CH:10]=[C:9]([Cl:13])[C:8]=2[Cl:14])=[CH:4][NH:5][CH:6]=1.[C:15](N1C=CN=C1)(=[O:17])[CH3:16]>>[C:15]([N:5]1[CH:6]=[C:2]([Cl:1])[C:3]([C:7]2[CH:12]=[CH:11][CH:10]=[C:9]([Cl:13])[C:8]=2[Cl:14])=[CH:4]1)(=[O:17])[CH3:16]

Participants

3

Reactant 2

HCID 171741-(1H-Imidazol-1-yl)ethanoneHCID 128838083-Chloro-4-(2,3-dichlorophenyl)-1H-pyrrole

Product 1

HCID 12832895HCID 12832895, compoundYield 57%

Procedure

The mixture of 0.3 g of 4-chloro-3-(2,3-dichlorophenyl)pyrol and 0.6 g of N-acetylimidazole was fused for one hour at 140° C. in a stream of argon. The resulting reaction mixture was purified by thin-layer chromatography to obtain 0.2 g of the desired product (colorless or slightly colored crystal, m.p. 97° C.).

Workup

  1. customThe resulting reaction mixture
  2. customwas purified by thin-layer chromatography

Sources & evidence

ORD record
ord-d2efaa575344480ba19b4f1f5e5dbd03
Source dataset
uspto-grants-1982_04
Patent number
US04326881

Reaction notes

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