HCID 73682984, compound → HCID 20542074, compound

HRID 2286169Notes

Reaction equation

HRID 2286169 reaction equation
[CH2:1]([N:3]1[C:9]2[CH:10]=[CH:11][C:12]([C:14](=[N:16]O)[CH3:15])=[CH:13][C:8]=2[C:7]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=2[F:24])=[N:6][CH2:5][C:4]1=[O:25])[CH3:2].[H][H]>C(O)C.[Ni]>[NH2:16][CH:14]([C:12]1[CH:11]=[CH:10][C:9]2[N:3]([CH2:1][CH3:2])[C:4](=[O:25])[CH2:5][N:6]=[C:7]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[F:24])[C:8]=2[CH:13]=1)[CH3:15]

Participants

5

Reactant 2

HCID 73682984HCID 73682984, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 20542074HCID 20542074, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 702EthanolSolvent

Procedure

A solution of 1 g (2.95 mmol) of 1-ethyl-5-(o-fluorophenyl)-1,3-dihydro-7-[1-(hydroxyimino)ethyl]-2H-1,4-benzodiazepin-2-one in 150 ml of ethanol is stirred with 1.0 g of Raney-nickel paste for 21 hours in a hydrogen atmosphere at 50°. After filtration over Digalite and evaporation in vacuo, there is obtained 7-(1-aminoethyl)-1-ethyl-5-(o-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one of melting point 53°-55°.

Workup

  1. filtrationAfter filtration
  2. customover Digalite and evaporation in vacuo

Sources & evidence

ORD record
ord-560562280ffe4a0b876656e89661dba7
Source dataset
uspto-grants-1982_04
Patent number
US04327026

Reaction notes

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