HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 73682984, compound → HCID 20542074, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 73682984 | HCID 73682984 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 20542074 | HCID 20542074 | — |
Reaction Steps
A solution of 1 g (2.95 mmol) of 1-ethyl-5-(o-fluorophenyl)-1,3-dihydro-7-[1-(hydroxyimino)ethyl]-2H-1,4-benzodiazepin-2-one in 150 ml of ethanol is stirred with 1.0 g of Raney-nickel paste for 21 hours in a hydrogen atmosphere at 50°. After filtration over Digalite and evaporation in vacuo, there is obtained 7-(1-aminoethyl)-1-ethyl-5-(o-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one of melting point 53°-55°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04327026 |
| Source dataset | uspto-grants-1982_04 |
| ORD ID | ord-560562280ffe4a0b876656e89661dba7 |
| Source note | uspto-grants-1982_04 |